Targeted Protein Degradation Technologies

Targeted Protein Degradation Technologies by Jiangjiang Qin, Xin Luan, Weidong Zhang delivers a clear, practical roadmap to one of the most transformative areas in drug discovery. From the fundamentals of the ubiquitin-proteasome system to frontline advances in PROTACs, molecular glues, and E3 ligase engineering, this book captures the science and strategies that are reshaping therapeutics worldwide.

Begin with a concise, authoritative overview that hooks readers new to targeted protein degradation and satisfies experienced researchers seeking technical depth. Detailed chapters translate complex concepts into actionable workflows: ligand design and optimization, structure-guided approaches, biochemical and cellular assays, hit-finding strategies, and in vivo validation. Real-world examples and case studies illustrate how chemistry and biology converge to degrade disease-driving proteins.

For medicinal chemists, chemical biologists, pharmacologists, and R&D leaders, this volume is a strategic asset. It highlights experimental best practices, troubleshooting tips, and decision-making frameworks that accelerate lead development and translational programs. Whether you’re in academia, biotech, or pharmaceutical development—labs in North America, Europe, and Asia will find the content directly applicable to contemporary projects.

Readable, rigorously referenced, and forward-looking, this book equips teams to navigate regulatory, design, and efficacy challenges as targeted degradation moves toward the clinic. If you want a single, practical reference to guide design, experimentation, and program planning in targeted protein degradation, Targeted Protein Degradation Technologies is an essential addition to your laboratory and library. Purchase now to bring cutting-edge degradation strategies into your workflow.

Note: eBooks do not include supplementary materials such as CDs, access codes, etc.